Medina Sidonia and the Inquisition: when the richest duke faced the most feared institution.

The House of Medina Sidonia is one of the most prominent lineages of Spanish nobility, with a history dating back to the 15th century. The dukes, such as Don Juan Manuel Pérez de Guzmán, enjoyed immense wealth, possessing more than 100,000 ducats in 1550, thanks to their properties in Andalusia and their control over trade with the Americas. Their palace in Sanlúcar de Barrameda is a symbol of their opulence. However, their history is intertwined with the Inquisition, a feared institution that threatened their grandeur and challenged their power.

December 8, 2025

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Medina Sidonia: The Richest Duke Who Challenged the Inquisition

The history of Spanish nobility is marked by epic confrontations, palace intrigues, and a myriad of rumors that swirl through the court like a torrent. However, few tales are as fascinating as that of the House of Medina Sidonia, a lineage that reached the pinnacle of greatness while simultaneously becoming entangled in the feared machinery of the Inquisition. In a setting where extreme power and wealth intertwine with fear and decay, the Duke of Medina Sidonia stands as a monumental figure, whose audacity defied one of the most dreaded institutions in history: the Inquisition.

A Lineage of Greatness: The House of Medina Sidonia

The House of Medina Sidonia is undoubtedly one of the most illustrious lineages of Spanish nobility, with a history that dates back to the 15th century. From its founding, the dukes of Medina Sidonia enjoyed disproportionate wealth, thanks to their vast estates in Andalusia and their control over the trade route with the Americas. Documents from the Municipal Archive of Medina Sidonia reveal that in 1550, the family possessed over 100,000 ducats, an exorbitant sum for that time.

The dukes, such as Don Juan Manuel Pérez de Guzmán y de la Cerda, who took possession of the title in 1580, were known for their ostentatious lifestyle. The construction of their palace in Sanlúcar de Barrameda, an architectural gem that can still be visited today, reflects their love for grandeur. With halls adorned with paintings by renowned artists and a collection of artworks that rivaled those of the finest European courts, the duke lived in a world of luxury. However, behind this façade of splendor lay a conflict that would change the course of their history.

The Inquisition: The Power Lurking in the Shadows

The Inquisition, established in 1478, had risen as the iron hand of the Church, enforcing religious orthodoxy and instilling fear across the realm. Its relentless pursuit of heretics and dissenters created an atmosphere of paranoia, where even the noblest of families could find themselves ensnared in its web. The Duke of Medina Sidonia, with his immense wealth and influence, was not immune to its reach.